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In addition, different cell death patterns might happen and contribute to the pathology of disease at the same time

miR-145 was also shown to modulate IGF-1 signaling pathway by directly targeting IGF-1R in HCC (Su et al., 2009), but its role other cancer remained unknown ( Amplified IGF-1/IGF-1R signaling has been associated with increased relative risk for development of colorectal cancer (CRC) as well as CRC metastasis, and resistance to chemotherapeutic drugs (Weber et al., 2002

Both oxidative damage to cells and reduced antioxidant capacity contribute to this disease

CNS/neuronal models: DES-IGF-1's natural occurrence in brain tissue has made it a subject of interest in neurological research, where locally produced truncated IGF-1 may play developmental roles