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If a cell hits a critical temperature, the chain reaction can be hard to stop

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Although there are some cardioprotective benefits to LC supplementation in certain situations (such as lowering all-cause mortality after MI), the formation of TMAO that goes along with it raises questions regarding long-term cardiovascular safety, particularly for people who already have heart issues [83]

There are rare naturally occurring apoE mutations other than apoE 2/2 that have been associated with a dominant form of dysbetalipoproteinemia that is expressed at an early age