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These results demonstrated a marked increase in glucose and total bilirubin, as well as a marked decrease in total protein and albumin in the HCD-supplemented group when compared to the other groups, while the HCD & probiotic-supplemented group exhibited a marked decrease in glucose and total bilirubin, as well as a significant increase in total protein when compared to the HCD group

Additionally, EGCG modulates key signaling pathways implicated in ischemic pathology, including the PI3K/AKT/mTOR axis, NF-B, and MAPK pathways, resulting in reduced pro-inflammatory cytokine production and suppression of microglial activation (146)

Looking Ahead The 2025 clinical research landscape is defined by both resurgence and reinvention

While VR-based cognitive training shows promise as an early intervention for SCD, further research is needed to determine whether it can effectively prevent or slow cognitive decline in this population