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These methyltransferases all utilize SAM as the methyl donor and incorporate the methyl group onto lysine residues, arginine residues, and histidine residues in proteins

The natural cycle also slows down due to environmental factors

doi: 10.1111/and.2018.50.issue-8 4 WalczakJedrzejowskaRWolskiJKSlowikowskaHilczerJ

In macrophage and microglial models, fisetin was reported to downregulate iNOS, COX-2, and TNF-, while inhibiting the nuclear translocation of NF-B (p65) and phosphorylation of upstream kinases such as Src, Syk, and JNK [54,55,56]
