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In 2000, Mark Heiman and Matthias Tschp discovered that ghrelin acts in the brain to regulate food intake, body weight, adiposity, and glucose metabolism [2]

therefore, the authors of the study suggested that the MT-1 inhibition could be a therapeutic attractive target to restore and preserve insulin secretion in patients with T2DM [129]

SIRT1 counters oxidative stress by deacetylating transcription factors such as Nrf2, thereby increasing the expression of antioxidant enzymes that reduce ROS production (Nagappan et al., 2020)

For HPLC measurement, a mixture of acetonitrile and 0.1% formic acid solution (95: 5, v/v) was used as an eluent at a flow rate of 0.3 mL/min
