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(2025) 13:e0157624
Dysregulation of HSP activity can lead to aberrant inflammasome activation, resulting in the excessive production of pro-inflammatory cytokines and contributing to the pathogenesis of autoimmune diseases such as SLE, RA, and MS
This oxidative stress damages mitochondrial DNA and surrounding cellular structures, further impairing energy output
Animal studies also examined the AOD9604 mechanism of action at the molecular level, confirming that the peptide works through beta-3 adrenergic receptor activation and downstream stimulation of lipolysis
