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Stratifications based on the three factors showed different between-study heterogeneities for several subgroups (eFig
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It is to note that the patients presenting with severe neurological manifestations were usually excluded by our team for the oral vitamin B12 treatment

However, whereas a small shift of the 2- and 3-OH groups of the ribose by approximately 1 can be observed for compound 7a that is possibly induced by the highly strained and bend conformation of the linker, this is not the case for compound 7b (Figure S3, A and B)
