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Zhao, Y., Jin, L

This mechanism is plausible, but the word liposomal does not guarantee that a product contains stable, well-formed liposomes or that it has been tested in humans

[3] The most important product is 2,3-bisphosphoglycerate (2,3-BPG), an allosteric effector of hemoglobin that reduces its affinity for molecular oxygen, thereby facilitating its release at the tissue level

For the exon skipping efficacy test, BC-derived primary cells (3 10 cells per well) were seeded in a 6-well plate, and the most promising AON was selected by transfecting 300 nM AON using Lipofectamine RNAiMAX reagent (Invitrogen, Thermo Fisher Scientific, #13778075) according to the manufacturers instructions