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In vivo studies have shown that intravenously administered NAC reaches high concentrations in organs such as the lungs (320 M), kidneys (250 M), heart (170 M), and liver (100 M), with peak concentrations in human red blood cells reaching 200 M

On the basis of the results available up to date, the Global Initiative for Chronic Obstructive Lung Disease [119] recognizes that mucolytic and antioxidant drugs, such as NAC, can be used as an adjunct therapy to reduce the risk of acute exacerbation of COPD, but in a limited way due to the lack of robust randomized controlled clinical trials (level of evidence B)

Across neurons and glia, mitochondria provide bioenergetic support, regulate Ca 2+ dynamics and reactive oxygen species levels, influence neurotransmitter synthesis and turnover, and sustain quality control programmes that preserve cellular integrity

It is extensively used as a reference compound in a number of in vitro AT assays (MacDonald-Wicks et al., 2006)