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Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74

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It was previously approved by the FDA for diagnostic evaluation and treatment of pediatric GH deficiency and is now widely used off-label in research and clinical settings to address adult-onset GH insufficiency and age-related hormonal decline

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