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In this review, we will explore the function of GH and IGF in regulating normal ovarian and testicular physiology, while also investigating the effects on cell signal transduction pathways with subsequent changes in cell proliferation and steroidogenesis

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Ethics declarations Approval of the Research Protocol This work is funded by the School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran (MUMS) (Project No: 4011353) and approved by the ethical committee of Mashhad University of Medical Sciences (approval code: IR.MUMS.AEC.1402.012)