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To produce models to investigate LHON, researchers have generated iPSCs with mutations in the MT-ND4 gene (G11778A) to differentiate neurons and retinal ganglion cells (Yang et al., 2020

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Greater progress in the clinic has been achieved with neutralization of inhaled virus by inhaling recombinant human ACE2 (NCT04396067 phase II of retinoic acid for COVID-19 and NCT05065645 phase I for ACE2 for COVID-19) and unfractionated heparin (NCT05184101, phase II and phase III of heparin for COVID-19)

In regions with low macrolide resistance, vonoprazan-based therapy with clarithromycin and metronidazole may be considered