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It prevented and reversed hepatocyte enlargement, fatty liver changes, and liver weight increases

Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations

From a research perspective this validates the angiogenic mechanism of GHK-Cu, similar to BPC-157 and TB-500

This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance