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When pretreated with antibodies to integrins alpha 1 and beta 1, MSC failed to produce an increase of VEGF, which indicated that the effects of GHK on secretion of trophic factors by MSC involve the integrin cellular pathway [30]

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The goal of this project was to chemically modify this tripeptide in such a way to enhance its metabolic stability and barrier permeability to produce a drug candidate with potential clinical utility

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