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Additional reports have detailed the wide range of bioenergetic insults that APOE4 expression can cause in the brain, including impaired insulin signaling 19,20 , reduced cerebral blood volume and cognitive function in response to a high fat diet (HFD) 21,22 , altered genetic expression of glucose-regulating enzymes and transporters 23,24 , and the generation of a toxic C-terminal fragment of apoE4 that can directly target electron transport chain (ETC) complexes in the mitochondria 25,26,27

Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2010

H., Matheson, P