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This is because CKD can cause damage to kidneys, making them less able to filter these substances from the blood, which may lead to certain health complications

10.1007/s00401-012-1009-1 120

doi: 10.1016/j.brainres.2022.148134 4 CapursoC.PanzaF.SeripaD.FrisardiV.ImbimboB

conducted a rare variant analysis of 4,241 PAH patients and identified seven genes significantly associated with idiopathic PAH, offering novel insights into PAH pathogenesis and potential therapeutic targets (46)
