glutathione and pulmonary hypertension Ferroptosis-Mediated Inflammation Promotes Pathophysiology and Management of Persistent
Description
In decompensated cirrhosis, CD8 + T cell numbers are decreased, CD4/CD8 ratios are altered, and T cell proliferation increases, but activation and exhaustion markers are lost
Therefore, although GSH-deficient T lymphocytes will be activated normally at first, they cannot reprogram their metabolism to meet their increasing energy requirements, resulting in T lymphocytes ferroptosis and causing immune dysfunction (62)
Wu Y, Mi C, Wen W
[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Tang L., Choe K.P
