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Importantly, the majority of sulforaphanes neuroprotective effects are mediated by NRF2, since the absence of NRF2 prevents sulforaphanes effects (Innamorato et al., 2008
More than 20 years ago it was concluded that the cytosol contains essentially no free Cu(I) or Zn(II) [207,209]
It induces ferroptosis by ubiquitinating GPX4 ( 3.1.3 Other classes of natural compounds There are other various classes of compounds that exhibit different effects on ferroptosis
