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Vegetables In the general population, people should eat at least two and a half servings of vegetables a day but ideally five servings per day [56]

Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical

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5, 6, 7 Such an experimental effort culminated in 1978 with the approval of CDDP by the US Food and Drug Administration (FDA) for use in testicular and bladder cancer patients