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However, side effects related to poor absorption, such as nausea and constipation, are common and frequently limit the use of ferrous salts (Winkelman 2025

Vitamin C administration enhanced Treg proliferation and inhibited the negative immunoregulation of Tregs by inhibiting the expression of specific transcription factors, antigens, and cytokines [89]

These findings suggest that valine (or BCAA more generally) is a relatively minor contributor to the pool of C3 in normal or MMA hepatocytes, given the lack of effect of the BCATi on M0 C3 or total C3
