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For example, melanocytoma can develop de novo, despite being considered an intermediate stage between nevus and melanoma

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With one of these, rs11559024 [C] (MAF=2.15%, Glu83Gly), we replicated a reported association 12

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Although melanomas are melanocytic tumors, they differ in cell type, age of onset, clinical and histologic manifestations, metastatic pattern, ethnic distribution, role of ultraviolet radiation in disease onset, predisposing changes in the germline, mutational processes, and pattern of somatic mutations [1]

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