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These include: Extreme weight loss Addiction Severe dental problems (sometimes referred to as meth mouth) Intense itching, which leads to skin sores from scratching Anxiety Confusion Memory loss Sleeping problems Violent behavior Paranoiaextreme and unreasonable distrust of others Hallucinationsexperiencing sensations or seeing images that seem real but arent Long-term meth use also alters parts of the brains dopamine system, resulting in reduced coordination and impaired verbal learning

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Golgi localized beta1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCepsilon to regulate cardiac hypertrophy