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4 The role of macrophages in PAH 4.1 Macrophage polarization and pulmonary vascular inflammation Extensive infiltration of macrophages around the pulmonary vasculature is a pathological feature observed in both patients with PAH and animal models, as supported by substantial evidence ( In the monocrotaline (MCT)-induced rat model of PAH, early accumulation of M1 macrophages around the pulmonary vasculature can be observed, accompanied by high expression of inducible iNOS and IL-1 ( 4.1.1 The role of M2 macrophages in inflammation M2 macrophages serve as crucial immunomodulators within the inflammatory network

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