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Khader M et al
doi: 10.1186/s12916-022-02415-z 267 ChauKHennessyAMakrisA
Mechanistically, PKM2 lactylation alters its conformation to a preferential tetrameric over its otherwise dimeric/monomeric form, and thereby reduces PKM2 nuclear accumulation, where it would otherwise drive the expression of proglycolytic genes in interaction with HIF1 (Wang et al., 2022) as well as pro-inflammatory genes (Shirai et al., 2016)
Clinically relevant doses of vitamin A decrease cortical bone mass in mice
