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Research has shown that intestinal bacteria play a role in the initial development of human AD [81]

This result is consistent with the intended role of the framework as a sensitivity-preserving screening tool that prioritizes plausible BBB-penetrating peptides for downstream experimental follow-up, rather than imposing an overly conservative filter at the initial screening stage

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The initial research used crude organ extracts (cytomedins): epithalamin from pineal gland, thymalin from thymus, cortexin from brain cortex