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2 Major invasive fungal pathogens and their drug resistance status Fungi represent a major biological kingdom with an extensive evolutionary history, comprising an estimated global diversity of over 5 million species, among which more than one million have been formally identified (Schueffler and Anke, 2014

thus, it inhibits histamine release by eliminating ROS in mast cells ( 2.5 Contact Dermatitis Contact dermatitis is a common inflammatory skin disorder that is usually characterized by alternating relief from and deterioration of symptoms, but it can be persistent at times ( 3 Trx1 Mechanisms 3.1 Eliminating ROS and Maintaining Redox Balance Trx1 can directly remove ROS produced in inflamed tissues and help maintain redox balance