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A significant proportion of APAP overdoses are known to be chronic in nature and/or associated with long-term exposure to APAP at doses above those recommended by the manufacturer (Daly et al

Combination regimens with CQ/HCQ improve outcomes when paired with radiation therapy in brain metastases, 284,285 HDAC inhibitors such as vorinostat, 286 mTOR inhibitors such as temsirolimus, 287 temozolomide, 288 proteasome inhibitors such as bortezomib, 289 gemcitabine in pancreatic ductal adenocarcinoma, 290 and erlotinib in non-small cell lung cancer (Fig

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