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[DOI] [PubMed] [Google Scholar] 5.Sutton D.A., Moldofsky H., Badley E.M

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J Biol Chem 281(21):1484114851

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Recent data also suggest that hydroxyurea may upregulate GPx-1 expression in several cell lines and in circulating erythrocytes, in part, by a p53-dependent pathway, providing evidence that p53-mechanisms modulate GPx-1 expression in vivo (68)

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Targeting p53 presents a substantial risk of off-target effects

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