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Meanwhile, sustained IGF-1 elevation above 300 ng/mL has been associated with increased colorectal and breast cancer risk in epidemiological data (Renehan et al., Lancet 2004)
doi: 10.1038/ncomms11463 220 MillmanJRPagliucaFW
This investigation highlighted also that miR-302a suppressed osteosarcoma metastases through targeting IGF1R, and this may provide a novel target to prevent metastasis in osteosarcoma patients
