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10.1038/s41598-023-34182-z Sci

Additionally, 1.1 million children and adolescents aged 1419 years have T1DM, as estimated by the International Diabetes Federation (IDF), and without interventions to stop the rise in diabetes, by 2045, there will be at least 629 million diabetic patients [6]

The tip of the microvilli is always relatively hypoxic compared to the base, and in reduced perfusion states, oxygen will tend to move down a gradient from arteriole to venule closer to the base, thus exacerbating hypoxia at the tip and potentially switching apoptosis to necrosis in epithelial cells

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