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Description
Intramuscular injection delivers absolute bioavailability between 14 to 20% compared to intravenous dosing

Joint pain (chronic knee, shoulder, hip): Anti-inflammatory effects can begin at 2 to 3 weeks

The oscillation activation of PARP-1 interacts with and poly(ADP-ribosyl)ates CLOCK, leading to suppressed binding of CLOCK: BMAL1 to DNA and altered circadian gene expression

Declaration of competing interest None
