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Mechanistically, the upregulation of CTR1 required Smads-dependent TGF- signaling pathway and Smad3 directly binded to the promoter of CTR1 in renal fibroblast cells using chromatin immunoprecipitation

When the body's tissues become less responsive to insulin, a condition known as insulin resistance, it increases the risk of type 2 diabetes mellitus (T2DM), metabolic syndrome, fatty liver disease, and atherosclerosis (Lee et al., 2022)

Lussu M, Noto A, Masili A, Rinaldi AC, Dess A, Angelis MD, et al