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These hydrolytic enzymes are typically confined to lysosomal compartments, but like cathepsin B, they can be secreted by tumor cells in necrotic areas
Enzyme-instructed self-assembly (EISA) and hydrogelation of peptides
For example, phage OMKO1 infects PsA and selects for evolved phage resistance that coincides with reduced multidrug efflux (Mex) pump function to achieve reduced antibiotic resistance 9 , a trade-off previously exploited in a clinical case of phage therapy 10
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