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For instance, although PC3, BT-549, and HOP-92 cells exhibit some of the highest labile intracellular Cu levels, exposure to the TC-Py ligand resulted in low micromolar GI 50 values (14.45, 12.59, and 1.20 M, respectively), comparable to those observed in cell lines with relatively low labile Cu, such as MCF7, T47D, and OVCAR-8 (9.12, 6.03, and 2.69 M, respectively)

10.1097/mpa.0b013e318150e4f2 210 OjinoK.ShimazawaM.OhnoY.OtsukaT.TsurumaK.HaraH

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Despite important advances in mapping cellular and molecular processes in cutaneous repair, translating traditional phytomedicines into safe, effective wound therapies requires a coordinated research pipeline that explicitly links ethnobotanical knowledge to mechanistic and toxicological evaluation