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Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells

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Gupta, The multifaceted role of glutathione S-transferases in cancer

Moreover, SFN is considered to possess negligible toxic effects and effectively traverses the bloodbrain barrier in mice after intraperitoneal administration, potentially increasing brain-derived neurotrophic factor (BDNF) levels and enhancing dendritic spine density due to its direct impact on neurons, while also providing protection against oxidative stress via the Keap1-Nrf2 pathway (102)