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Polygenic risk scores (PRS) incorporating PNPLA3, TM6SF2, and MBOAT7 can predict the likelihood of developing liver fat accumulation, inflammation and fibrosis and help to identify individuals at high risk of liver disease progression, particularly in situations where liver biopsy is not possible or practical [281]

In the diet, lignans often occur as complex precursors (like secoisolariciresinol diglucoside in flax) that are metabolized by gut microbiota into bioactive forms (54)

During oxidative stress there is decrease in levels of GSH and increase in levels of GSSG and thus GSH/GSSG ratio decreases

We segmented the mass spectrometry (MS) images using seven 13 C-labelled metabolites from glycolysis ([U- 13 C]pyruvate, [U- 13 C]lactate) and the TCA cycle ([ 13 C 2 ]fumarate, [ 13 C 2 ]succinate, [ 13 C 2 ]malate, [ 13 C 2 ]glutamate and [ 13 C 2 ]glutamine)