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Encoded by both nuclear and mitochondrial DNA, they play a crucial role in maintaining cellular activities, as well as supporting the structure, function, and regulation of tissues and organs ( Protein oxidation begins when the hydroxyl radical abstracts a hydrogen atom from the protein, generating an alkyl radical stabilized by resonance with the carboxyl group

In eukaryotic cells, GSH is very important, in yeast cells needed as a reductant, which may serve to eliminate endogenously produced toxic metabolites (Cooper and Hanigan, 2018

Biochem.114, 383387 (1981)

This inhibition led to a reduction in glycolytic rate and capacity in HCC cells (Fig