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Liver dysfunction can manifest in nails as very pale nails (due to reduced blood perfusion or anemia), Terrys nails (a whitened proximal half with a darker distal band) or spoon nails in chronic cases

Reactive species derived from oxidative stress generally have a very short half-life 24 so their detection in serum is very limited, making the analysis of products derived from oxidation of great interest

Early Sleep Changes Patients May Notice Patients often notice sleep shifts that feel more gradual than intense

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