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In vitro permeation tests on human cadaver skin demonstrated increased permeability of different-sized hydrophilic proteins, such as FITC-BSA (67 kDa) and FITC-Insulin (6 kDa) via direct penetration

5-amino-1MQ - This peptide is known for its antioxidant properties and its ability to protect cells from damage caused by free radicals

Females live longer than males: role of oxidative stress

The right panel describes strategies for managing peak-dose dyskinesias (involuntary movements during ON periods), which include reducing individual levodopa doses to lower the dopaminergic load or adding Amantadine to suppress the dyskinesia