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Given the important central role of this cofactor and its relevance to mitochondrial function, this review will provide an extensive summary of the NAD + homeostasis and modulation approaches, of the various mechanisms of NAD + -mediated mitochondrial regulation, and how the functional link between NAD + and mitochondria has been investigated in the context of preclinical and clinical settings of aging and disease

doi: 10.1371/journal.pone.0225931

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Several reviews discuss the potential benefits of NO and H 2 S availability in biological systems and the association of decreased levels with the development of cardiovascular diseases and an increased risk of pathogenic events [138,139,140]