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Furthermore, Lion's Mane has been investigated for its potential to reduce symptoms of anxiety and depression, which can indirectly impact cognitive performance [5]

260 This is particularly important in view of the facts that (i) several anticancer regimens operate by eliciting or boosting anticancer immunity, some of them by altering the immunopeptidome of malignant cells 264, 265 and that (ii) CDDP is generally considered as a non-immunogenic anticancer agent

Therapeutic inhibition of IGF-1R or downstream AKT/ERK signalingcould therefore potentiate immune checkpoint therapy by restoring MHC-I presentation and reducing PD-L1 expression

This decreases inflammatory cell infiltration and protects surrounding tissues from secondary damage 4