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Mechanistically, the role of KHK in alcohol preference is most likely due to the role of fructose metabolism in the activity levels of aldehyde dehydrogenase (ALDH), the mitochondrial enzyme that metabolizes the toxic intermediate in ethanol metabolism, acetaldehyde
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doi:10.1126/scitranslmed.abe1433 564. Ngo ML, Mahdi F, Kolte D, Shariat-Madar Z
