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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

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A., Hankinson S

Its expression can be induced by various abiotic stresses, including high-salt stress, drought, hydrogen peroxide, salicylic acid, methyl jasmonate, and abscisic acid