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CYP2E1, an ROS-generating enzyme of the cytochrome P450 family, is overexpressed in MASLD and contributes to both mitochondrial and microsomal ROS accumulation
ME/CFS has been described as a fluctuating condition as symptoms change in nature and severity sporadically (40)
A 2024 systematic review published in the International Journal of Molecular Sciences analyzed 25 human studies and identified exercise-related markers as among the areas where preliminary results appear most consistent, though the review emphasizes these are early-stage findings requiring larger confirmatory trials
