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CD98 transports BCAA and aromatic amino acids into the cell and consists of 2 subunits, Slc7a5 or CD98 light chain (CD98lc) and Slc3a2 or CD98 heavy chain (CD98hc)

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Major reactive species, including ROS and reactive nitrogen species (RNS) consist of paramagnetic free radicals (superoxide O 2 - , hydroxyl HO , peroxy ROO , and nitric oxide free radical NO ) and diamagnetic molecules (hydrogen peroxide H 2 O 2 and peroxynitrite ONOO - ) which are products of the reactions of these free radicals

A better understanding of epigenetic modifications, such as DNA methylation, is expected to compliment information on genome processes, including molecular, cellular, biological, and immune responses, and provide deeper insights on how they interact to define phenotypic outcome