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Blockade of LCAC-mediated I Na(L) is also suggested to reduce the metabolic deficit developed with LCAC treatment (Maruyama et al., 2000
This includes the upregulation of genes encoding acetyl-CoA carboxylase alpha (ACACA), elongase of very long chain FAs 1 (Elovl1), Elovl5, Elovl6, fatty acid synthase (FASN) , and stearoyl-CoA desaturase 2 (SCD2)
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