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Acknowledgements This study was supported by Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital for facilities, and with the grant support of the Ministry of Science and Technology, TAIWAN, under grants nos 104-2221-E-182-034, 104-2314-B-039-058,104-2314-B-039-058, 105-2221-E-182-022, 105-2221-E-182-022, 105-2923-B-002-001-MY3, Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW107-TDU-B-212-113004), and by Chang Gung Memorial Hospital, TAIWAN, under grants nos CIRPD2E0051-53, CMRPD2D0111-13, and CMRPG3D1061-3

Additionally, to determine the influence of elevated temperature, PhIP transformation activities by reuterin solutions and acrolein (10 mM) were evaluated at 37 C

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For chronic conditions, expect 8-12 weeks minimum