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Therefore, presenting with the normalized pressures in the BPC 157-rats, abrogated organs lesions and counteracted thrombosis, these activated shunts represent the rapidly established alternative equilibrium, which is well functioning (i.e., consistently maintained undisturbed blood pressure in the superior sagittal sinus) in the compensation of the otherwise harmful conditions of the central venous occlusion

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When activated by a nociceptive stimulus, they release mediators including calcitonin gene related peptide and nitric oxide

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