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The interface with the second largest buried surface area in the Tyk2 crystal lattice did place the C- and N-termini in close enough proximity to be linked by the interdomain linker, and this interface was investigated in detail and mutational data did support the biological significance of this interaction surface

The dual role of ROS underscores the need for controlled redox modulation while excessive ROS disrupts healing, physiological levels drive angiogenesis, fibroblast activation, and cell migration

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