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Transient receptor potential (TRP) channels have also been found to regulate the proliferation, migration and differentiation of cardiac fibroblasts, as well as the synthesis and secretion of ECM (266)

AOD9604 is the hGH fragment 177-191 with an additional tyrosine at the N-terminus, which stabilizes the molecule

Furthermore, regional differences in prevalence, genotype distribution and patterns of consanguinity, together with heterogeneity in CBS mutations and pyridoxine responsiveness, may limit the generalizability of certain therapeutic approaches or outcome expectations across diverse patient populations

10.1002/art.41511